Publications

You can find the complete list of our publications from our Google Scholar account.

Tumor heterogeneity and rare subtypes / brain tumor genomic characterization :

  1. Genomic profiling of sporadic multiple meningiomas. Erson-Omay, E.Z., Vetsa, S., Vasandani, S. et al. Genomic profiling of sporadic multiple meningiomas. BMC Med Genomics 15, 112 (2022).
  2. Longitudinal analysis of treatment-induced genomic alterations in gliomas. Erson-Omay EZ, Henegariu O, Omay SB, Harmancı AS, Youngblood MW, Mishra-Gorur K, Li J, Özduman K, Carrión-Grant G, Clark VE, Çağlar C, Bakırcıoğlu M, Pamir MN, Tabar V, Vortmeyer AO, Bilguvar K, Yasuno K, DeAngelis LM, Baehring JM, Moliterno J, Günel M.. Genome Medicine 2017, 9:12.
  3. Somatic POLE mutations cause an ultramutated giant cell high-grade glioma subtype with better prognosis. Erson-Omay EZ, Çaglayan AO, Schultz N, Weinhold N, Omay SB, Özduman K, Köksal Y, Li J, Serin Harmanci A, Clark V, Carrión-Grant G, Baranoski J, Çaglar C, Barak T, Coskun S, Baran B, Köse D, Sun J, Bakircioglu M, Moliterno Günel J, Pamir MN, Mishra-Gorur K, Bilguvar K, Yasuno K, Vortmeyer A, Huttner AJ, Sander C, Günel M. Somatic POLE mutations cause an ultramutated giant cell high-grade glioma subtype with better prognosis. Neuro-oncology 2015, 17:1356-64.
  4. Genomic analysis of non-NF2 meningiomas reveals mutations in TRAF7, KLF4, AKT1, and SMO. Clark VE, Erson-Omay EZ, Serin A, Yin J, Cotney J, Ozduman K, Avsar T, Li J, Murray PB, Henegariu O, Yilmaz S, Günel JM, Carrión-Grant G, Yilmaz B, Grady C, Tanrikulu B, Bakircioglu M, Kaymakçalan H, Caglayan AO, Sencar L, Ceyhun E, Atik AF, Bayri Y, Bai H, Kolb LE, Hebert RM, Omay SB, Mishra-Gorur K, Choi M, Overton JD, Holland EC, Mane S, State MW, Bilgüvar K, Baehring JM, Gutin PH, Piepmeier JM, Vortmeyer A, Brennan CW, Pamir MN, Kiliç T, Lifton RP, Noonan JP, Yasuno K, Günel M. Genomic analysis of non-NF2 meningiomas reveals mutations in TRAF7, KLF4, AKT1, and SMO. Science (New York, N.Y.) 2013, 339:1077-80.
  5. Integrated genomic characterization of IDH1-mutant glioma malignant progression. Bai H, Harmanci AS, Erson-Omay EZ, Li J, Coskun S, Simon M, Krischek B, Özduman K, Omay SB, Sorensen EA, Turcan S, Bakirciglu M, Carrión-Grant G, Murray PB, Clark VE, Ercan-Sencicek AG, Knight J, Sencar L, Altinok S, Kaulen LD, Gülez B, Timmer M, Schramm J, Mishra-Gorur K, Henegariu O, Moliterno J, Louvi A, Chan TA, Tannheimer SL, Pamir MN, Vortmeyer AO, Bilguvar K, Yasuno K, Günel M. Integrated genomic characterization of IDH1-mutant glioma malignant progression. Nature Genetics 2016, 48:59-66.

Precision Medicine :

  1. Hypermutated phenotype in gliosarcoma of the spinal cord. Hong CS, Kuzmik GA, Kundishora AJ, Elsamadicy AA, Koo AB, McGuone D, Blondin NA, DiLuna ML, Erson-Omay EZ. Hypermutated phenotype in gliosarcoma of the spinal cord. NPJ Precision Oncology 2021, 5:8.
  2. Dual activating FGFR1 mutations in pediatric pilomyxoid astrocytoma. Fomchenko EI, Reeves BC, Sullivan W, Marks AM, Huttner A, Kahle KT, Erson-Omay EZ. Dual activating FGFR1 mutations in pediatric pilomyxoid astrocytoma. Molecular Genetics & Genomic Medicine 2021, 9:e1597.
  3. Genetic characterization of an aggressive optic nerve pilocytic glioma. Hong CS, Fliney G, Fisayo A, An Y, Gopal PP, Omuro A, Pointdujour-Lim R, Erson-Omay EZ, Omay SB. Genetic characterization of an aggressive optic nerve pilocytic glioma. Brain Tumor Pathology 2021, 38:59-63.
  4. Persistent STAG2 mutation despite multimodal therapy in recurrent pediatric glioblastoma. Hong CS, Vasquez JC, Kundishora AJ, Elsamadicy AA, Beckta JM, Sule A, Marks AM, Leelatian N, Huttner A, Bindra RS, DiLuna ML, Kahle KT, Erson-Omay EZ. Persistent STAG2 mutation despite multimodal therapy in recurrent pediatric glioblastoma. NPJ Genomic Medicine 2020, 5:23.
  5. Genetic characterization of a case of sellar metastasis from bronchial carcinoid neuroendocrine tumor. Christopher S H, Kundishora AJ, Elsamadicy AA, Koo AB, Beckta JM, McGuone D, Erson-Omay EZ, Omay SB. Genetic characterization of a case of sellar metastasis from bronchial carcinoid neuroendocrine tumor. Surgical Neurology International 2020, 11:303.
  6. Novel EWSR1-VGLL1 fusion in a pediatric neuroepithelial neoplasm. Kundishora AJ, Benjamin Reeves BA, Nelson-Williams C, Hong CS, Gopal PP, Snuderl M, Kahle KT, Omay EZE. Novel EWSR1-VGLL1 fusion in a pediatric neuroepithelial neoplasm. Clinical Genetics 2020, 97:791-792.
  7. Somatic NF1 mutations in pituitary adenomas: Report of two cases. Hong CS, Kundishora AJ, Elsamadicy AA, Koo AB, McGuone D, Inzucchi SE, Omay SB, Erson-Omay EZ. Somatic NF1 mutations in pituitary adenomas: Report of two cases. Cancer Genetics 2021, 256-257:26-30.
  8. Genomic alterations underlying spinal metastases in pediatric H3K27M-mutant pineal parenchymal tumor of intermediate differentiation: case report. Fomchenko EI, Erson-Omay EZ, Kundishora AJ, Hong CS, Daniel AA, Allocco A, Duy PQ, Darbinyan A, Marks AM, DiLuna ML, Kahle KT, Huttner A. Genomic alterations underlying spinal metastases in pediatric H3K27M-mutant pineal parenchymal tumor of intermediate differentiation: case report. Journal Of Neurosurgery. Pediatrics 2019, 1-10.
  9. A novel finding of an IDH2 mutation in an interesting adult Sonic Hedgehog mutated medulloblastoma. Fomchenko EI, Erson-Omay EZ, Moliterno J. A novel finding of an IDH2 mutation in an interesting adult Sonic Hedgehog mutated medulloblastoma. Journal Of Neuro-oncology 2019, 144:231-233.
  10. DNMT3A co-mutation in an IDH1-mutant glioblastoma. Fomchenko EI, Erson-Omay EZ, Zhao A, Bindra RS, Huttner A, Fulbright RK, Moliterno J. DNMT3A co-mutation in an IDH1-mutant glioblastoma. Cold Spring Harbor Molecular Case Studies 2019, 5.
  11. De novo MYH9 mutation in congenital scalp hemangioma. Fomchenko EI, Duran D, Jin SC, Dong W, Erson-Omay EZ, Antwi P, Allocco A, Gaillard JR, Huttner A, Gunel M, DiLuna ML, Kahle KT. De novo MYH9 mutation in congenital scalp hemangioma. Cold Spring Harbor Molecular Case Studies 2018, 4.
  12. Biallelic inactivation of PBRM1 as a molecular driver in a rare pineoblastoma case: illustrative case. JP Antonios, K Yalcin, A Darbinyan, A Koo, CS Hong… – Journal of Neurosurgery: Case Lessons, 2022

Other cancer types/diseases:

  1. Paediatric hepatocellular carcinoma due to somatic CTNNB1 and NFE2L2 mutations in the setting of inherited bi-allelic ABCB11 mutations. Vilarinho S, Erson-Omay EZ, Harmanci AS, Morotti R, Carrion-Grant G, Baranoski J, Knisely AS, Ekong U, Emre S, Yasuno K, Bilguvar K, Günel M. Paediatric hepatocellular carcinoma due to somatic CTNNB1 and NFE2L2 mutations in the setting of inherited bi-allelic ABCB11 mutations. Journal Of Hepatology 2014, 61:1178-83.
  2. Whole-Exome Sequencing of an Exceptional Longevity Cohort. Nygaard HB, Erson-Omay EZ, Wu X, Kent BA, Bernales CQ, Evans DM, Farrer MJ, Vilariño-Güell C, Strittmatter SM. Whole-Exome Sequencing of an Exceptional Longevity Cohort. The Journals Of Gerontology. Series A, Biological Sciences And Medical Sciences 2019, 74:1386-1390.
  3. Exome analysis of the evolutionary path of hepatocellular adenoma-carcinoma transition, vascular invasion and brain dissemination. Vilarinho S, Erson-Omay Z, Mitchell-Richards K, Cha C, Nelson-Williams C, Harmancı AS, Yasuno K, Günel M, Taddei TH. Exome analysis of the evolutionary path of hepatocellular adenoma-carcinoma transition, vascular invasion and brain dissemination. Journal Of Hepatology 2017, 67:186-191.

Software/methods:

  1. PATIKAweb: a Web interface for analyzing biological pathways through advanced querying and visualization. Dogrusoz U, Erson EZ, Giral E, Demir E, Babur O, Cetintas A, Colak R. PATIKAweb: a Web interface for analyzing biological pathways through advanced querying and visualization. Bioinformatics (Oxford, England) 2006, 22:374-5.
  2. A software framework for multiscale and multilevel physiological model integration and simulation. Erson EZ, Cavuşoğlu MC. A software framework for multiscale and multilevel physiological model integration and simulation. Annual International Conference Of The IEEE Engineering In Medicine And Biology Society. IEEE Engineering In Medicine And Biology Society. Annual International Conference 2008, 2008:5449-53.
  3. Design of a framework for modeling, integration and simulation of physiological models. Erson E, Cavusoglu M. Design of a framework for modeling, integration and simulation of physiological models. Annual International Conference Of The IEEE Engineering In Medicine And Biology Society. IEEE Engineering In Medicine And Biology Society. Annual International Conference 2010, 2010:1485-9.
  4. Design of a framework for modeling, integration and simulation of physiological models. Erson EZ, Cavuşoğlu MC. Design of a framework for modeling, integration and simulation of physiological models. Computer Methods And Programs In Biomedicine 2012, 107:524-37.