Department of Neurosurgery
Yale School of Medicine
New Haven, CT
Our research is focused on studying and understanding the multi-omic (genomic/transcriptomic/epigenetic) profiles of various tumors through computational methods. Specifically, interested in genomic profiles of primary brain tumors with a focus on inter and intra tumor heterogeneity.
Also, we develop bioinformatics approaches to study large datasets to reveal the molecular mechanisms both in tumor formation, progression, and also in clinical outlier subgroups such as; treatment resistant/responsive or long/short term survivors. In addition, we are interested in application of genomic techniques to precision medicine efforts at the Department of Neurosurgery at Yale since 2016.
Major Areas of Inquiry
Tumor Ecosystem
We employ diverse omics technologies to explore the intricate interactions among cells such as tumor and immune cells in various types of brain tumors.
Tumor Evolution and Heterogenity
We are working with various omics datasets to enhance our comprehension of tumor evolution and heterogeneity in temporal and spatial dimensions.
Precision Medicine
Tumors, especially brain tumors with high inter and intra tumor heterogeneity, require personalized approaches or prognosis and identification the most effective treatment modalities. Deciphering the molecular architecture for each and every tumor is essential for precision medicine efforts to succeed. We are using and developing computational analysis methods to guide the genomic characterization arm of precision medicine efforts at Yale.
THE ERSON LAB 