GENOMIC HETEROGENEITY IN PRIMARY BRAIN TUMORS
Tumors are highly heterogenous entities that evolve in time under the pressure of treatment or just to survive. We are interested in understanding how the genomic profiles of these tumors change in temporal or spatial dimension, and how these changes affect the response to treatment.
EZ Erson-Omay, et.al. – BMC Medical Genomics, 2022
- Somatic POLE mutations cause an ultramutated giant cell high-grade glioma subtype with better prognosis
EZ Erson-Omay, AO Çağlayan, N Schultz, N Weinhold… – Neuro-oncology, 2015
EZ Erson-Omay, et.al. – Genome medicine, 2017
CS Hong, et.al. – NPJ Genomic Medicine, 2020
MOLECULAR PRECISION MEDICINE FOR PRIMARY BRAIN TUMORS
Tumors, especially brain tumors with high inter and intra tumor heterogeneity, require personalized approaches for most effective treatments. Deciphering the molecular architecture for each and every tumor is essential for precision medicine efforts to succeed.We are using and developing computational analysis methods to guide the genomic characterization arm of precision medicine efforts at Yale.
AJ Kundishora, et.al.- Clinical genetics, 2020
CS Hong, et.al. – NPJ precision oncology, 2021
SINGLE CELL AND SPATIAL RESOLUTION BRAIN TUMOR MULTI-OMICS
Single cell multi-omics is an emerging technique providing solutions to many inherent problems of various brain tumors that hampered the discovery of molecular mechanisms. We are building our preliminary data and infrastructure to apply these techniques to many interesting problems.
BIOINFORMATICS ANALYSIS COLLABORATIONS
We love to collaborate ! Over the years we worked with other labs across different departments on other cancer types, neurodegenerative diseases and clinical research. We will keep working with our colleagues and expand our interests.
- Paediatric hepatocellular carcinoma due to somatic CTNNB1 and NFE2L2 mutations in the setting of inherited bi-allelic ABCB11 mutations
S Vilarinho*, EZ Erson-Omay*, AS Harmanci, R Morotti, G Carrion-Grant, … Journal of hepatology 61 (5), 1178-1183, 2014
SSM Nygaard HB, Erson-Omay EZ, Wu X, Kent BA, Bernales CQ, Evans DM, Farrer …J Gerontol A Biol Sci Med Sci, 2018
- Exome Analysis of the Evolutionary Path of Hepatocellular Adenoma-Carcinoma Transition, Vascular Invasion and Brain Dissemination
S Vilarinho, EZ Erson-Omay, K Mitchell-Richards, C Cha, …J Hepatol., 2017
- Mutations in KATNB1 cause complex cerebral malformations by disrupting asymmetrically dividing neural progenitors
K Mishra-Gorur, AO Çağlayan, AE Schaffer, C Chabu… – Neuron, 2014